Chemotherapy has been proven an effective treatment for cancer. It is able to suppress the spread of cancer cells throughout a patient’s body by targeting and killing cells that divide rapidly. Unfortunately, the treatment also affects cells that divide rapidly under normal circumstances, such as cells in the digestive tract, bone marrow and hair follicles. Cancer patients undergoing long term chemotherapeutic treatment, then, suffer such conditions as baldness, liver toxicity, and a weakened immune system.
A team of researchers from Tel Aviv University, led by Dr. Dan Peer and Prof. Rimona Margalit, have found a way to eliminate these debilitating side effects. Setting their sights on finding a solution to narrow down the attacking scope of chemotherapy, the team has developed a nano-sized vehicle that can deliver chemotherapy drugs directly into cancer cells while avoiding interaction with healthy cells. With this breakthrough technology, not only will side effects greatly be reduced, but the efficiency of chemotherapeutic treatment will also improve.
Dr. Peer explains that the nano-vehicle is similar to a cluster bomb. Inside the tiny module are tiny particles of chemotherapy drugs. When the vehicle comes into contact with a cancer cell, it automatically releases the drugs into it. Because the attack is contained within the cell, the cytotoxic substances can be more potent without seriously affecting neighboring healthy cells, even if their behavior is similar to that of cancer cells.
This new form of nano-device-assisted chemotherapy can be used to treat numerous types of cancer, including that of the breasts, lungs, colon, and even cancers of the brain or blood. Clinical trials are already underway, with Dr. Peer and Prof. Margalit working with ORUUS Pharma in California. The company recently licensed the “cluster bomb” platform from the Israeli university. With further fine-tuning, the treatment may prove to be one of the best improvements for modern cancer treatment in recent history.